A Mississippi River Odyssey

Spanning 800 km along the mighty Mississippi River, this section of the Great River Road weaves through bluffs, historic towns, and wildlife-rich wetlands. From the river’s headwaters to its dramatic southern bends, here’s your guide to exploring three states shared aquatic lifeline:

Begin where the St. Croix River meets the Mississippi. Fuel up in Prescott and pick up a Great River Road Passport for stamps at key stops.

Key Stops & Highlights

1. Red Wing. Barn Bluff: Hike for panoramic river views. Red Wing Shoe Museum: Celebrate the town’s iconic footwear legacy.
2. Lake City. Lake Pepin: Birthplace of water-skiing. Rent a kayak or watch bald eagles soar in winter.
3. Wabasha. National Eagle Center: Meet rescued bald eagles and learn about river ecology.
4. La Crosse. Grandad Bluff: Drive up for a 360° vista of three states. Riverside Park: Stroll along the riverwalk or catch a sunset riverboat cruise.
5. Effigy Mounds National Monument. Hike trails past 1,000-year-old Native American burial mounds shaped like bears and birds.
6. Dubuque. National Mississippi River Museum: Interactive exhibits on river history. Fenelon Place Elevator: Ride the world’s steepest scenic railway.
7. McGregor/Marquette. Pikes Peak State Park: Overlook the river’s confluence with the Wisconsin River.

Conclude in Keokuk, home to the Lock & Dam No. 19, where you can watch barges navigate the river’s final Iowa stretch.

Tips for the Drive

• Road Conditions: Mix of two-lane highways and scenic byways. Watch for cyclists.
• Wildlife: Bring binoculars for eagles, herons, and river otters.
• Season: Fall (Sept–Oct) for fiery bluffs; spring (Apr–May) for migrating birds.
• Local Eats: Cheese curds (WI), walleye sandwiches (MN), and Dutch letters (IA pastries).

For route details, events, and downloadable guides: experiencemississippiriver.com